Native Human Lp-PLA2 Antigen
Catalog No: 24331302N
Quantity: 0.1 mg
Alternate Names: LDL-PLA2; LP-PLA2; PAFAD; PAFAF
Lipoprotein-associated phospholipase A2, also knownas platelet-activating factor acetylhydrolase (PAF-AH), is a phospholipase A2enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDaprotein of 441 amino acids. It is one of several PAF acetylhydrolases. Lp-PLA2is involved in the development of atherosclerosis, an observation that hasprompted interest as a possible therapeutic target (see, e.g. theinvestigational drug Darapladib). In human atherosclerotic lesions, 2 mainsources of Lp-PLA2 can be identified, including that which is brought into theintima bound to LDL (from the circulation), and that which is synthesized denovo by plaque inflammatory cells (macrophages, T cells, mast cells)."
It is used as a marker for cardiac disease.
Formulation: Liquid, supplied in PBS buffer, pH 8.0, containing 0.05%sodium azide.
Applications: Excellent for use as a control or calibrator.
Precaution: Sodium azide is a poisonous and hazardous substance whichshould be handled by trained staff only.
Fig 1. 1 ug ofpurified Lp-PLA2 protein on SDS-PAGE gel.
Storage & Stability: Stable at 4Â°C for shipping purposes and short term storage.
Upon receipt, store at -20Â°C.After reconstitution, store in working aliquots at -20Â°C to -80Â°C. Avoid repeatedfreeze-thaw cycles.
NOT FOR HUMAN USE. FOR RESEARCH ONLY. NOT FOR THERAPEUTICUSE.